Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…obvious clinically. The earliest findings observed by us are a lichenoid peri-infundibular infiltrate of lymphocytes followed by progressive peri-infundibular fibroplasia. As time goes on, the lichenoid infiltrate wanes and the fibrosis waxes, eventu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.47.1A: Perivascular dermatitis, interface, patchy lichenoid + 10.47.1B: Keratocytes with steel-gray nuclei, “margination” of chromatin, ballooned cytoplasm, and multinucleate and necrotic keratocytes = Infection by h…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

“-oid (-oid) [eides, like]. A suffix signifying likeness or resemblance.” Bould G. The Practitioner’s Medical Dictionary. 3rd ed. Philadelphia, PA: P. Blakiston’s Son & Co., 1916:622. “-ode, -odes, -oid, -oides […

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Palpable Purpura?

…in the papillary dermis and often in the epidermis itself. The lichenoid purpura of Gougerot and Blum (lichen aureus), at an early stage of its course chronologic, consists entirely of purpuric papules. Those papules are fashioned of lichenoid infilt…

Differential Diagnosis in Dermatopathology

Lichen nitidus vs. Lichen striatus

A condition in which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a syst…

Clinical Case Studies

Graft-Versus-Host Disease

INITIAL PRESENTATION A 38-year-old Filipino male presented with lichen planus-like plaques and dyspigmentation of the hands, lips, and oral mucosa. Eight months earlier he had received an allogeneic bone marrow transplant for the treatment of a hema…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Common Baldness—an Inflammatory Disease?

“The results also show that inflammation in MPA [male pattern alopecia] is a relatively consistent finding and that, although often insignificant, this frequently leads to an inflammatory folliculitis, perifollicular fibrosis, and unusually…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eczema?

“Eczema is that which looks like eczema.” Hebra F. Kaposi M. Lehrbuch der Hautkrankheiten. Bd, 2. Aufl. Erlangen: Enke, 1874:403-93. “In Anglo-American usage, the term dermatitis is being used increasingly for all these conditi…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

See Fig. 5.307 A&B. Figure 5.307 Pustular dermatitis. A. Infundibular. B. Surface epidermal. Although most pustules in skin are housed in infundibular epidermis (Fig. 5.308 A&B), many are lodged in surface epidermis (Fig. 5.309 A&B)….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.57.1A: Nodular dermatitis and panniculitis, granulomatous + 10.57.1B: Lymphocytes among dense infiltrates of slightly foamy histiocytes, some of them having a bluish cast + 10.57.1C + 10.57.1D = Leprosy, lepromatous…