Differential Diagnosis in Dermatopathology

Discussions

…undles of collagen arranged haphazardly. Within the epidermis, lymphocytes are disposed mostly as solitary units and are accompanied by scant spongiosis. Other clues to diagnosis of patches of mycosis fungoides are lymphocytes in the epidermis larger…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

…pongiosis and ballooning in foci epidermal Few neutrophils and lymphocytes in spongiotic foci Fully developed Perivascular and interstitial infiltrate of lymphocytes and neutrophils Marked edema of the papillary dermis Interface between epidermis a…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

See Fig. 5.350 A&B. Figure 5.350 Fibrosing dermatitis. A. Early. B. Late (sclerosis). Fibrosing dermatitis (as well as fibrosing peri-infundibulitis/perifolliculitis and fibrosing panniculitis) results, in every instance, from injury to nonep…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.103.1A: Perivascular dermatitis, psoriasiform lichenoid + 10.103.1B: Infiltrate of histiocytes, plasma cells, lymphocytes, and neutrophils, edema of the papillary dermis, and neutrophils in the acanthotic epidermis, including in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.21.1A: Perivascular and interstitial dermatitis, interface, vacuolar + 10.21.1B: Few lymphocytes, abundant mucin, an epidermis thin focally, and parakeratosis = Dermatomyositis A paltry infiltrate of inflammatory cells helps in…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent light reaction

…icial and deep perivascular and patchy lichenoid infiltrate of lymphocytes, plasma cells, and eosinophils; some lymphocytes may be larger than normal Papillary dermis thickened also by coarse bundles of collagen disposed in vertical streaks Plump, st…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rmis and are joined there a day or so later by eosinophils and lymphocytes. 10.88.7A: Vesicular dermatitis, intraepidermal, ballooning + 10.88.7B: Neutrophils joined by lymphocytes and eosinophils in a zone of reticular alteration = Prurigo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…derately dense superficial and deep perivascular infiltrate of lymphocytes unaccompanied by any changes at the dermoepidermal junction or in the epidermis. It is a description, not a diagnosis. Diseases characterized by infiltrates of lymphocytes aro…

Histologic Diagnosis of Inflammatory Skin Diseases

Sarcoidosis

…her of those findings being specific for sarcoidosis Few or no lymphocytes at the periphery of collections of epithelioid histiocytes; granulomas, at times, surrounded by numerous lymphocytes, especially when present in lobules in the subcutaneous fa…