Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Borderline, Minimal Deviation, and Nevoid Melanomas?

…iation melanoma have been described . . . A small nodule of melanocytes that show moderate to moderately severe atypism and impinge on the reticular dermis . . . Minimal deviation melanomas that share some histologic features with a Spitz tumor. Ha…

Clinical Case Studies

Nevus of Ota

…logy and pathogenesis are unknown, Nevus of Ota may represent melanocytes that failed to completely migrate from the neural crest to the epidermis during the embryonic stage.2 The two peak ages of onset are during early infancy and adolescence; this…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Precursor Lesions of Melanoma?

…part from the fact that all of them are neoplasms composed of melanocytes, they have nothing in common! Lentigo maligna is a synonym for a flat lesion of melanoma (melanoma in situ) situated on skin that has been damaged badly by the effects of ultra…

Dermatology Practical & Conceptual

Balloon cell melanoma in primary care practice: a case report

…sitioned atypical aggregates of grossly distended epithelioid melanocytes, exhibiting a pseudo-xanthomatous balloon cell change in their cytoplasm, and pleomorphic vesicular nuclei with nucleoli. These cells did not mature with descent, exhibited 4 m…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Changing Mole?

…Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al., eds., Dermatology in general medicine. 4th ed. New York: McGraw-Hill, 1993:1001. Family physicians should be aware that a pati…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…tic Fibrosis. San Francisco: San Francisco Press, 1982:35-52. Melanocytes Boissy RE. The melanocyte. Its structure, function, and subpopulations in skin, eyes, and hair. Dermatol Clin 1988;6:161-173. Riley PA. Melanin. Int J Biochem Cell Biol 1997;29…

Histologic Diagnosis of Inflammatory Skin Diseases

Post-inflammatory pigmentary alteration

…ned from keratocytes especially, but it also is released from melanocytes and is ingested by macrophages that come to reside in the papillary dermis. When the epidermis of such a lesion houses an increased amount of melanin, the result is postinflamm…