Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

…ieved to occupy the gray zone separating benign and malignant neoplasms of the sweat glands. Since none was found to have metastasized, this lesion is provisionally considered benign. The diagnostic term of papillary eccrine adenoma is suggested.” Th…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Differential Diagnosis in Dermatopathology

Apocrine (clear-cell) hidradenoma vs. Eccrine (poroid) hidradenoma

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…s and associated papilla present often 11. No hamartomas or neoplasms with adnexal differentiation concurrent in the section of tissue 11. Benign neoplasms with adnexal differentiation (e.g., trichoblastoma) and much less commonly malignant neoplas…

Differential Diagnosis in Dermatopathology

Discussions

…ogically as squamous-cell carcinoma. Granular-cell tumors are neoplasms, whereas xanthomas are not, sometimes being a manifestation of a metabolic disorder. Involvement of nerve fascicles by neoplastic cells may be observed in granular-cell tumors, t…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

…ells of a swelling), pathologists would do better to refer to neoplasms and neoplastic cells (despite the limitations of those terms as becomes apparent in a later chapter). Having thus employed words with more precision, they will, justifiably, swel…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…anular cells of hamartomas like fibrous papules and in benign neoplasms like granular-cell schwannoma), and to epithelial patterns in the skin that lack specificity, such as the focal acantholytic dyskeratosis that occurs in noninflammatory diseases…