Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

…issue of eccrine versus apocrine differentiation of cutaneous neoplasms affiliated with tubules, Dermatopatholology: Practical & Conceptual. 2003;9(4). 34. Crowson AN, Magro CM, Mihm MC. Malignant adnexal neoplasms. Mod Pathol. 2006; Suppl 2:S93…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…

Differential Diagnosis in Dermatopathology

Discussions

The most important finding that granular-cell tumors and xanthomas have in common is diffuse dermal infiltrates of monomorphous cells that possess abundant pale-staining cytoplasm. The cytoplasm may have either a basophilic or eosinophilic hue in se…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eruptive Vellus Hair Cyst?

“From the histologic viewpoint, EVHC [eruptive vellus hair cyst] must be differentiated from steatocystoma multiplex.” Gonzalez FU, Cristobal MC, Martinez AA, et al. Eruptive vellus hair cyst with singular histologic finding. Arch Derm…

Differential Diagnosis in Dermatopathology

Discussions

…indings crucial for differentiation histopathologic of the two neoplasms of abnormal melanocytes under discussion here are the same ones that apply in distinguishing benign from malignant neoplasms in general, namely, architectural pattern, silhouett…

Clinical Case Studies

Extensive Actinic Damage

INITIAL PRESENTATION A 67-year-old Caucasian male presented with severe photodamage of his face and scalp and a history of multiple nonmelanoma skin cancers. (Figure 1) The patient had been treated with radiation for adolescent acne vulgaris. One ye…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

“With the high power the hyaline is seen in very varied forms, which all show the same fuchsin red reaction. The first forms a section by itself; it comprises hyaline balls of different size, which lie free between the epithelial cells, and w…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

“This is a study of the clinical features of four patients in the light of particular cutaneous histopathology. The characteristic eruption is periodic, tending to recur every few months, usually without systemic symptoms. The acute state of…