Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ms and associated papilla present often 11. No hamartomas or neoplasms with adnexal differentiation concurrent in the section of tissue 11. Benign neoplasms with adnexal differentiation (e.g., trichoblastoma) and much less commonly malignant neopla…

Differential Diagnosis in Dermatopathology

Apocrine (clear-cell) hidradenoma vs. Eccrine (poroid) hidradenoma

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Differential Diagnosis in Dermatopathology

Granular-cell tumor vs. Xanthoma

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

…issue of eccrine versus apocrine differentiation of cutaneous neoplasms affiliated with tubules, Dermatopatholology: Practical & Conceptual. 2003;9(4). 34. Crowson AN, Magro CM, Mihm MC. Malignant adnexal neoplasms. Mod Pathol. 2006; Suppl 2:S93…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…

Differential Diagnosis in Dermatopathology

Discussions

The most important finding that granular-cell tumors and xanthomas have in common is diffuse dermal infiltrates of monomorphous cells that possess abundant pale-staining cytoplasm. The cytoplasm may have either a basophilic or eosinophilic hue in se…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eruptive Vellus Hair Cyst?

“From the histologic viewpoint, EVHC [eruptive vellus hair cyst] must be differentiated from steatocystoma multiplex.” Gonzalez FU, Cristobal MC, Martinez AA, et al. Eruptive vellus hair cyst with singular histologic finding. Arch Derm…

Differential Diagnosis in Dermatopathology

Discussions

…indings crucial for differentiation histopathologic of the two neoplasms of abnormal melanocytes under discussion here are the same ones that apply in distinguishing benign from malignant neoplasms in general, namely, architectural pattern, silhouett…