Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

…issue of eccrine versus apocrine differentiation of cutaneous neoplasms affiliated with tubules, Dermatopatholology: Practical & Conceptual. 2003;9(4). 34. Crowson AN, Magro CM, Mihm MC. Malignant adnexal neoplasms. Mod Pathol. 2006; Suppl 2:S93…

Differential Diagnosis in Dermatopathology

Discussions

In general, neoplasms metastatic to the skin present little difficulty in differential diagnosis from neoplasms primary in the skin. Carcinoma of the breast is an exception. If there are but a few neoplastic cells and numerous inflammatory cells sca…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ms and associated papilla present often 11. No hamartomas or neoplasms with adnexal differentiation concurrent in the section of tissue 11. Benign neoplasms with adnexal differentiation (e.g., trichoblastoma) and much less commonly malignant neopla…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

“Melanoma arising from lentigo maligna is preceded by or forms a part of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in…

Differential Diagnosis in Dermatopathology

Discussions

…indings crucial for differentiation histopathologic of the two neoplasms of abnormal melanocytes under discussion here are the same ones that apply in distinguishing benign from malignant neoplasms in general, namely, architectural pattern, silhouett…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

“With the high power the hyaline is seen in very varied forms, which all show the same fuchsin red reaction. The first forms a section by itself; it comprises hyaline balls of different size, which lie free between the epithelial cells, and w…

Differential Diagnosis in Dermatopathology

Discussions

Dermatofibroma and dermatofibrosarcoma protuberans are lesions made up of dense diffuse infiltrates of mesenchymal cells in company with bundles of collagen, the two together occupying at least much of the thickness of the dermis and sometimes part…

Clinical Case Studies

Extensive Actinic Damage

INITIAL PRESENTATION A 67-year-old Caucasian male presented with severe photodamage of his face and scalp and a history of multiple nonmelanoma skin cancers. (Figure 1) The patient had been treated with radiation for adolescent acne vulgaris. One ye…