Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…ytes arranged compactly, it is not possible to comprehend why psoriasis at those sites may appear as spongiotic vesicles. Knowledge of the function of the skin in general, and of each component of it, is requisite if the effects of inflammatory skin…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…xanthoma have been said to represent one of the many faces of psoriasis, particularly the verrucous expression of it. The changes common to both are verrucous outline, epidermal hyperplasia with elongated rete ridges of nearly equal length, parakerat…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…. In time, the epidermal basement membrane thickens. Eruptive psoriasis is devoid of interface changes, necrotic keratocytes, and ballooning. A fully developed lesion of prurigo pigmentosa is covered by a basket weave cornified layer and collections…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blaschkitis?

…y as so-called blaschkitis), linear lichen planus, and linear psoriasis. Because these are acquired disorders, it remains to be determined how previous tolerance to an abnormal cutaneous clone of cells can suddenly be altered. Last, a few words shoul…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…e, the psoriasiform “hyperplasia” of fully formed psoriasis or of long-standing nummular dermatitis. For another, the definition of hyperplasia turns largely on behavior of it, to wit, regression, yet involution cannot be recognized with…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

…atitis, dermatophytosis, pityriasis rosea, lichen planus, and psoriasis, consist of infiltrates of inflammatory cells that emerge from venules of the superficial plexus and migrate into at least the adjacent reticular dermis. In the case of pityriasi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus Versus Systemic Lupus Erythematosus?* I

…time, dermatologists and pathologists could never conceive of psoriasis, dermatitis herpetiformis, and granuloma faciale/erythema elevatum diutinum as manifestations of disease systemic. By the last quarter of the 20th century, however, the evidence…