Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

“A relationship most likely exists between the verruciform appearance of the epithelium and the underlying foam cells. . . . One might suspect that epithelial breakdown, from some as yet unknown cause may secondarily elicit a foam-cell respo…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

Capability for accurate diagnosis of inflammatory skin diseases, clinically and histopathologically, requires familiarity thoroughly with embryologic, histologic, and anatomic aspects of the skin. Although examples of this precept are legion, only a…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

An algorithm is a method for calculation based on logical thought and orderly sequence, one that can be utilized for diagnosis of diseases of all kinds, including inflammatory ones of the skin. Once a disorder of the skin and/or subcutaneous fat has…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…he manifestation accelerated extraordinarily, akin to pustular psoriasis vis-à-vis guttate psoriasis, bullous lichen planus vis-à-vis papular lichen planus, and bullous lupus erythematosus vis-à-vis “butterfly blush” and the latter being…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blaschkitis?

“Blaschkite de l’adulte is considered a new disease entity . . . described by Grosshans and Marot in their report of relapsing acquired unilateral skin lesions following Blaschko’s lines.” Megahed et al. Acquired relapsing…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

APOPTOSIS [Gk. apo- (away from) + ptosis (a falling)]: Reputed to be a specific type of cell death in which dead cells are said to undergo fragmentation by implosion with subsequent phagocytosis of nuclear debris (Fig. 3.40). The process is claimed…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…narily of a macule of conventional lichen planus, and pustular psoriasis, which is speeding up tremendously of a macule of guttate psoriasis. Degos’ disease, acral gangrene, i.e., of fingers and toes, and deep ulcers near internal malleoli are…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

Inflammation Belizova Z. Inflammatory disease? Dermatopathol: Prac & Concep 2004;10(2):8, available at www.derm101.com B?er A, Phadke V, Ackerman AB. Inflammatory disease—In search of a definition of a term employed commonly. Dermatopathol: Prac…