Histologic Diagnosis of Inflammatory Skin Diseases

Deep fungal infections

Deep fungal infections Synonyms Mycetoma Subcutaneous mycoses Dermal mycoses Presentation stereotypical Age and sex Any age, both sexes Distribution of lesions Localized or widespread; some infections favor exposed sites; internal organs sometimes…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.13.1A: Perivascular and interstitial dermatosis, infundibulocentric + 11.13.1B: Small lymphocytes, large abnormal lymphocytes, neutrophils and eosinophils = Lymphomatoid papulosis ¬†Episodically, as shown here, an infiltrate of l…

Histologic Diagnosis of Inflammatory Skin Diseases

Histiocytosis X

…ly in the upper part of the dermis. What seem clinically to be scales actually are scale-crusts formed by parakeratosis, serum, and inflammatory cells, especially neutrophils. Extravasation of red blood cells in the upper part of the dermis imparts t…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus foliaceus

…ers are apparent, whereas in others no blisters are seen, only scale-crusts being observable. That the scale-crusts are manifestations of a blistering disease may be inferred because they tend to be nearly perfectly round and when they become conflue…

Histologic Diagnosis of Inflammatory Skin Diseases

Gianotti-Crosti disease

…trier’s collections sometimes Focal parakeratosis and/or scale-crusts Late Same as in a lesion developed fully, but with less spongiosis, more acanthosis, and more prominent scale-crusts Correlation clinicopathologic Papules result from spon…

Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? In 1970, large cell acanthoma (LCA) was first described by Pinkus, as a sharply demarc…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

An inflammatory disease characterized by lesions with arcuate, annular, and serpiginous outlines and by collarettes of scale on the inner margin of lesions that extend outward in centrifugal fashion, disappearing in months as a rule in the absence o…

Differential Diagnosis in Dermatopathology

Pemphigus vulgaris vs. Grover’s disease, pemphigus vulgaris-like

An inflammatory disease characterized by lesions with arcuate, annular, and serpiginous outlines and by collarettes of scale on the inner margin of lesions that extend outward in centrifugal fashion, disappearing in months as a rule in the absence o…

Histologic Diagnosis of Inflammatory Skin Diseases

"Folliculitis" (Infundibulitis)

“Folliculitis” (Infundibulitis) Synonyms What is designated, universally, folliculitis is, in actuality, infundibulitis. In short, infundibulitis is NOT a synonym for folliculitis; the former, for purposes practical, is a suppurative pro…