Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…proposed. Ichthyosis vulgaris patients have dry skin and fine scales on their trunk and extremities, but gross changes in the skin of their legs may be more severe. A granular layer is histologically absent. Lamellar ichthyosis patients have large, c…

Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…a in the upper part of the dermis also may contribute. Subtle scale consists of parakeratotic cells. Differential diagnosis histopathologic Urticaria spares the epidermis, and the perivascular and interstitial infiltrate of it contains neutrophils,…

Histologic Diagnosis of Inflammatory Skin Diseases

Photoallergic dermatitis

…ongiotic vesicles Cornified layer either normal or covered by scale-crusts Late Superficial or superficial and deep perivascular and interstitial infiltrate of lymphocytes mostly Uneven psoriasiform acanthosis Slight focal spongiosis Scale-crusts…

Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

…n dots and globules, yellow opaque homogeneous areas, surface scale and a delicate, light brown, pseudonetwork commonly seen in solar lentigos. The prominent dermoscopic features in a case of ours were a brown, “broken up” pseudonetwork,…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

…ory disease characterized by lesions with arcuate, annular, and serpiginous outlines and by collarettes of scale on the inner margin of lesions that extend outward in centrifugal fashion, disappearing in months as a rule in the absence of treatment….

Histologic Diagnosis of Inflammatory Skin Diseases

Histiocytosis X

…rheic dermatitis: Denominators in common: Papules covered by scale-crusts. Features differentiating: Histiocytosis X differs clinically from seborrheic dermatitis by presence of purpura in papules. Findings histopathologic Fully developed Dense de…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus foliaceus

…of weeping lesions and crusts, rather than of dry lesions and scales, and by the absence of plugging of infundibula by corneocytes. Findings histopathologic Early Sparse superficial perivascular and interstitial infiltrate of lymphocytes, eosinophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Gianotti-Crosti disease

…rier’s collections sometimes Focal parakeratosis and/or scale-crusts Late Same as in a lesion developed fully, but with less spongiosis, more acanthosis, and more prominent scale-crusts Correlation clinicopathologic Papules result from spong…

Differential Diagnosis in Dermatopathology

Pemphigus vulgaris vs. Grover’s disease, pemphigus vulgaris-like

…ory disease characterized by lesions with arcuate, annular, and serpiginous outlines and by collarettes of scale on the inner margin of lesions that extend outward in centrifugal fashion, disappearing in months as a rule in the absence of treatment….