Histologic Diagnosis of Inflammatory Skin Diseases


…also in infundibular and surface epidermis, especially in the scale-crust. This condition, still thought by some authors to be related to Mucha-Habermann disease, is not an inflammatory process, but a CD 30 lymphoma. 11.13.6A: Perivascular and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology


…proposed. Ichthyosis vulgaris patients have dry skin and fine scales on their trunk and extremities, but gross changes in the skin of their legs may be more severe. A granular layer is histologically absent. Lamellar ichthyosis patients have large, c…

Histologic Diagnosis of Inflammatory Skin Diseases

Impetigo contagiosa

…show spongiform and subcorneal pustules, and in late lesions, scale-crusts laden with neutrophils. Clinically, bullous impetigo, which is nothing other than a blistering manifestation of impetigo contagiosa, may display both tense and flaccid blister…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…, and sacrum, and by the presence of burrows, as well as both scales and crusts, not just crusts alone. Denominators in common: Erosions secondary to excoriation and signs of lichen simplex chronicus. Features differentiating: Scabies differs cli…

Histologic Diagnosis of Inflammatory Skin Diseases

Histiocytosis X

…rheic dermatitis: Denominators in common: Papules covered by scale-crusts. Features differentiating: Histiocytosis X differs clinically from seborrheic dermatitis by presence of purpura in papules. Findings histopathologic Fully developed Dense de…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus foliaceus

…of weeping lesions and crusts, rather than of dry lesions and scales, and by the absence of plugging of infundibula by corneocytes. Findings histopathologic Early Sparse superficial perivascular and interstitial infiltrate of lymphocytes, eosinophi…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

…ory disease characterized by lesions with arcuate, annular, and serpiginous outlines and by collarettes of scale on the inner margin of lesions that extend outward in centrifugal fashion, disappearing in months as a rule in the absence of treatment….

Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

…n dots and globules, yellow opaque homogeneous areas, surface scale and a delicate, light brown, pseudonetwork commonly seen in solar lentigos. The prominent dermoscopic features in a case of ours were a brown, “broken up” pseudonetwork,…

Histologic Diagnosis of Inflammatory Skin Diseases

Gianotti-Crosti disease

…rier’s collections sometimes Focal parakeratosis and/or scale-crusts Late Same as in a lesion developed fully, but with less spongiosis, more acanthosis, and more prominent scale-crusts Correlation clinicopathologic Papules result from spong…