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Key Points Infection with various Borrelia species causes borreliosis, which may have cutaneous and systemic manifestations. This infection is transmitted through bites of the Ixodes species of ticks. Early Lyme disease (erythema chronicum migrans) and late Lyme disease (acrodermatitis chronicum atrophicans) are the classic cutaneous complications of these infections. Disseminated borreliosis may involve joints, heart, […]