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Key Points Darier’s disease is a genodermatosis of autosomal dominant inheritance causing abnormalities of keratinization stemming from defects in calcium regulation in keratinocytes. The classic skin manifestation is an eruption of hyperkeratotic papules, typically in a seborrheic distribution. Characteristic nail and mucous membrane involvement is common. Superinfection of the skin lesions of Darier’s may result […]