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First-line therapy: The first-line therapy for Darier’s disease is systemic retinoids. First steps The currently accepted primary treatment of moderate-to-severe Darier’s disease is systemic retinoids. Isotretinoin and acitretin are equally effective for most patients. Acitretin may be more effective for the hyperkeratotic lesions. For either medication, the starting dose is 0.2-0.3 mg/kg/day, with gradual escalation […]