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Therapy First-line therapy: Prompt identification and discontinuation of the offending agent is an essential first step. In most cases, the cutaneous reaction will resolve in 2-5 days without therapy; patients may continue to get new lesions during this time. Supportive therapy: Antihistamines, such as hydroxyzine (such as Atarax or Vistaril) 25-50 mg t.i.d. or q.i.d. […]