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Treatment Folliculitis First-line therapy: The first-line therapy for folliculitis includes the treatment of the appropriate cause, typically infection. A diagnostic biopsy or culture may be necessary to identify the inciting infectious cause. For Gram-positive folliculitis: dicloxacillin 250 mg q.i.d., oral erythromycin (in penicillin-allergic individuals) 250 mg q.i.d., or cephalexin 500 mg t.i.d. for 10 days. […]