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Key Points Viral infections by herpes simplex (HSV) typically occur in two locations: the orofacial (usually type I) and genital (usually type II). Infections may be primary, recurrent, in the setting of immunosuppression, or superinfection of a pre-existing skin disease (usually atopic dermatitis, e.g., eczema herpeticum). Acyclovir is almost always the first-line treatment given to […]