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Initial Evaluation Herpes zoster (shingles) Note that vesicles and papulovesicular lesions are grouped with an erythematous to hemorrhagic base. Primary varicella infection Differential diagnosis Herpes simplex virus (oral) Note that the vesiculopustular lesions of HSV are also grouped, as in zoster. Herpes simplex virus (genital) Eczema herpeticum Erythema multiforme