Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC)
Initial Evaluation: Squamous Cell Carcinoma
Predisposing factors for squamous cell carcinoma (SCC) include precursor lesions (actinic keratosis [AK], Bowens disease), UV exposure, ionizing radiation, environmental carcinogens (arsenic), immunosuppression, scars, burns, human papillomavirus (HPV), genodermatoses (xeroderma pigmentosum, albinism).
Squamous cell carcinomas of the skin have several key clinical features:
- Hyperkeratotic, erythematous papules and plaques
- Have superficial ulceration
- Typically occur on sun-exposed areas
- Carry a higher risk for metastasis than BCC