Non-Melanoma Skin Cancers (NMSC): Basal Cell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC)

Initial Evaluation: Squamous Cell Carcinoma

Predisposing factors for squamous cell carcinoma (SCC) include precursor lesions (actinic keratosis [AK], Bowen’s disease), UV exposure, ionizing radiation, environmental carcinogens (arsenic), immunosuppression, scars, burns, human papillomavirus (HPV), genodermatoses (xeroderma pigmentosum, albinism).

Squamous cell carcinomas of the skin have several key clinical features:

  • Hyperkeratotic, erythematous papules and plaques
  • Have superficial ulceration
  • Typically occur on sun-exposed areas
  • Carry a higher risk for metastasis than BCC