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Overview The etiology of this disorder is unknown and therapy is empiric. Treatment First steps Topical 5-fluorouracil (5-FU) 5% cream applied once or twice daily to lesions, until the epidermis desquamates and a crust forms, will often resolve superficial lesions. On thick-skinned areas, retinoic acid 0.1% cream or salicylic acid 6% gel may be added […]