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Overview In the absence of a primary cutaneous disorder, pruritus aniis thought to have two probable causes. One is irritation from rectal mucus and fecal material. The other is nerve impingement in the sacral region causing neuropathic itch. Rarely, pinworms, contact dermatitis, extramammary Paget’s disease, and streptococcal proctitis can cause perianal itching with minimal changes […]