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Key Points Indurated, often painful, erythematous nodules are the characteristic skin lesion that marks Sweet’s syndrome. Skin lesions may be bullous or cellulitis-like (pseudocellulitic) in appearance. Skin lesions of Sweet’s syndrome are often accompanied by signs of systemic inflammation: fever, malaise, arthralgias, and blood markers of inflammation such as leukocytosis or elevated erythrocyte sedimentation rate. […]