Search Results for: alpha-1%20antitrypsin%20deficiency

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Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…lving 4,118 patients demonstrated increased rates of achieving Psoriasis Area and Severity Index (PASI) scores of 75, 90, and 100% over placebo (risk ratios 12.61, 28.72, and 61.23, respectively). Therapy of plaque psoriasis Plaque psoriasis is the…

Therapeutic Strategies in Dermatology

Hidradenitis Suppurativa: Treatment

…to prevent development of antibiotic-resistant bacterial colonization. For severe disease, anti-tumor necrosis factor (TNF) alpha inhibitors can be highly effective and is supported by evidence. Of the available modalities, infliximab (5–8 mg/kg…

A Clinical Atlas of 101 Common Skin Diseases

Psoriasis

…pathogenesis of psoriasis features an interplay between adaptive and innate immunity centered on interleukin 23 and T-helper 17 cells (IL23/Th17 pathway). Morphologically, psoriasis presents with circumscribed erythematous macules that quickly…

Therapeutic Strategies in Dermatology

Lymphomatoid Papulosis: Overview

…twice daily to new lesions, followed by pulse therapy on weekends, may be effective and has minimal toxicity. Bexarotene gel 1% may be applied to early lesions as tolerated once or twice daily. This may prevent progression and speed healing….

Therapeutic Strategies in Dermatology

Behçet Syndrome: Overview

…olute avoidance of pregnancy is required. Patients with severe or multisystem disease are treated with prednisone starting at 1 mg/kg/day plus at times a steroid sparing agent. Azathioprine, chlorambucil, cyclosporine, methotrexate, and alpha

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…ed excision margins: European (Leiter U, et al. 2010) Melanoma in situ 0.5 cm 0.5 cm Breslow < 1 mm thickness 1 cm Breslow 1-2 mm 1-2 cm Breslow < 2 mm thickness 1 cm Breslow > 2 mm thickness 2 cm (at least) 2 cm Melanoma in situ should be…

Therapeutic Strategies in Dermatology

Ichthyoses/Disorders of Cornification: Overview

…agents (urea) are usually tried first. The efficacy of these agents are similar and the clinician may choose ammonium lactate 12% gel, lactic acid 6% lotion, or 40% urea in petrolatum with or without 5-10% lactic acid depending of the degree of…

Therapeutic Strategies in Dermatology

Raynaud’s Phenomenon/Disease: Overview

…ud’s phenomenon, drug treatment is beneficial. The calcium channel blockers amlodipine 2.5-10 mg once daily, nifedipine 10-30 mg 3 times daily, or diltiazem 30-60 mg four times daily will control symptoms in the majority of patients….

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…e of progression of the HIV-associated KS. The following staging system may be used: Stage I: Localized cutaneous (fewer than 10 lesions, or one anatomic region); Stage II: Disseminated cutaneous (more than 10 lesions, or more than one anatomic…

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