Search Results for: basement%20membrane

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Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…y affected. BP is an autoimmune condition wherein antibodies attack the hemidesmosome, the region of the epidermis where the basement keratinocytes adhere to the basement membrane zone and the underlying dermis. As such, antibodies and inflammation…

Therapeutic Strategies in Dermatology

Linear IgA Bullous Dermatosis: Initial Evaluation

…gy demonstrates a subepidermal bulla with a mixture of neutrophils and eosinophils. In early lesions, neutrophils lining the basement membrane zone accompanied by vacuolar changes and occasional neutrophilic microabscesses in dermal papillae are…

Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…including the conjunctivae. This disorder is thought to be mediated by autoantibodies directed at antigens in the epithelial basement membrane zone. The therapeutic strategy is to suppress the inflammatory reaction and eliminate the autoantibodies…

A Clinical Atlas of 101 Common Skin Diseases

Herpes Gestationis

Herpes gestationis is an inflammatory disease of the second and third trimesters of pregnancy characterized by widespread urticarial papules and plaques accompanied by vesicles and bullae. Individual lesions are indistinguishable from those of…

A Clinical Atlas of 101 Common Skin Diseases

Bullous Pemphigoid and Herpes Gestationis

Bullous pemphigoid is the most frequently occurring autoimmune vesiculobullous disease of the skin; it arises predominantly in the eighth or ninth decade of life. Signs include widespread erythematous macules and patches, urticarial papules and…

Therapeutic Strategies in Dermatology

Linear IgA Bullous Dermatosis: Key Points

…mediated mucocutaneous blistering disorder. It is characterized by the linear deposition of immunoglobulin A (IgA) along the basement membrane zone on direct immunofluorescence of the skin. LABD occurs in both adults and children and can be…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Clinical Case

…psy results, start with high potency topical corticosteroids Follow-up evaluation The biopsy demonstrates eosinophils at the basement membrane with epidermal spongiosis adjacent to a subepidermal blister filled with eosinophils; this is consistent…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…not diagnostic, indubitably, of lupus erythematosus. Figure 8.7 Lupus band. Granular deposits of IgG (A) and IgM (B) at the basement membrane zone. Granular deposits of two or more immunoglobulins at the basement membrane zone is indicative of a…

Therapeutic Strategies in Dermatology

Herpes Gestationis / Pemphigoid Gestationis: Introduction

…gG1 subclass autoantibodies directed against BPAG2, a transmembrane hemidesmosomal protein. Binding of autoantibodies to the basement membrane initiates an inflammatory reaction that causes blistering at the dermal-epidermal junction. The inciting…

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