Search Results for: basement%20membrane

1 2 3 10
Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…y affected. BP is an autoimmune condition wherein antibodies attack the hemidesmosome, the region of the epidermis where the basement keratinocytes adhere to the basement membrane zone and the underlying dermis. As such, antibodies and inflammation…

Therapeutic Strategies in Dermatology

Linear IgA Bullous Dermatosis: Initial Evaluation

…gy demonstrates a subepidermal bulla with a mixture of neutrophils and eosinophils. In early lesions, neutrophils lining the basement membrane zone accompanied by vacuolar changes and occasional neutrophilic microabscesses in dermal papillae are…

Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…including the conjunctivae. This disorder is thought to be mediated by autoantibodies directed at antigens in the epithelial basement membrane zone. The therapeutic strategy is to suppress the inflammatory reaction and eliminate the autoantibodies…

Therapeutic Strategies in Dermatology

Linear IgA Bullous Dermatosis: Key Points

…mediated mucocutaneous blistering disorder. It is characterized by the linear deposition of immunoglobulin A (IgA) along the basement membrane zone on direct immunofluorescence of the skin. LABD occurs in both adults and children and can be…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Clinical Case

…psy results, start with high potency topical corticosteroids Follow-up evaluation The biopsy demonstrates eosinophils at the basement membrane with epidermal spongiosis adjacent to a subepidermal blister filled with eosinophils; this is consistent…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…not diagnostic, indubitably, of lupus erythematosus. Figure 8.7 Lupus band. Granular deposits of IgG (A) and IgM (B) at the basement membrane zone. Granular deposits of two or more immunoglobulins at the basement membrane zone is indicative of a…

A Clinical Atlas of 101 Common Skin Diseases

Herpes Gestationis

An inflammatory disease of the second and third trimesters of pregnancy characterized by widespread urticarial papules and plaques accompanied by vesicles and bullae. Individual lesions are indistinguishable from those of bullous pemphigoid,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…ture) to 50% (our experience) of patients with epidermolysis bullosa acquisita have circulating IgG autoantibodies against a basement membrane component of normal skin detected by indirect immunofluorescence.” Briggaman et al., in 1985, found…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…ous units, apocrine units, and eccrine units. Moreover, the vasculature and Schwann cells of nerves also are surrounded by a basement membrane. Figure 1.70 Basement membrane zone as seen through a conventional microscope, namely, a band of periodic…

1 2 3 10