Search Results for: basement%20membrane

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Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…y affected. BP is an autoimmune condition wherein antibodies attack the hemidesmosome, the region of the epidermis where the basement keratinocytes adhere to the basement membrane zone and the underlying dermis. As such, antibodies and inflammation…

A Clinical Atlas of 101 Common Skin Diseases

Lupus Erythematosus

Lupus erythematosus (LE) is a multisystem autoimmune connective tissue disease that can have protean effects on the skin. In some patients only the skin is involved, while in others, life-threatening internal complications can arise, ranging from…

Therapeutic Strategies in Dermatology

Cicatricial Pemphigoid: Overview

…including the conjunctivae. This disorder is thought to be mediated by autoantibodies directed at antigens in the epithelial basement membrane zone. The therapeutic strategy is to suppress the inflammatory reaction and eliminate the autoantibodies…

Therapeutic Strategies in Dermatology

Chronic Bullous Disease of Childhood: Overview

…aracterized by the presence of multiple, tense bullae and severe itching in association with linear deposition of IgA at the basement membrane zone. The clinical appearance resembles bullous pemphigoid. It often remits 2-3 years after onset and…

A Clinical Atlas of 101 Common Skin Diseases

Bullous Pemphigoid and Herpes Gestationis

An inflammatory disease of older people; signs include widespread erythematous macules and patches, urticarial papules and plaques, and vesicles and bullae, the blisters often arising on urticarial plaques. Sometimes lesions are localized, e.g., to…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Clinical Case

…psy results, start with high potency topical corticosteroids Follow-up evaluation The biopsy demonstrates eosinophils at the basement membrane with epidermal spongiosis adjacent to a subepidermal blister filled with eosinophils; this is consistent…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Basement Membrane Zone Fluorescence

…not diagnostic, indubitably, of lupus erythematosus. Figure 8.7 Lupus band. Granular deposits of IgG (A) and IgM (B) at the basement membrane zone. Granular deposits of two or more immunoglobulins at the basement membrane zone is indicative of a…

A Clinical Atlas of 101 Common Skin Diseases

Dermatomyositis

An inflammatory disease of children and adults that tends to involve skin and skeletal muscle mostly, the findings in the skin being patches with the color of heliotrope, especially in the periocular region. The disease manifests itself as…

A Clinical Atlas of 101 Common Skin Diseases

Epidermolysis Bullosa

A constellation of unrelated blistering diseases, many of them determined genetically but some of them not, that involve skin and sometimes mucous membranes, the blisters often developing after trauma and sometimes resulting in scarring and…

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