Search Results for: cyclosporine%20toxicity

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…n tolerable doses of acitretin (10-25 mg daily), faster and more complete clearing, and lower cumulative doses of UV- light. Cyclosporine Cyclosporine (such as Neoral or Sandimmune) may be used to treat a variety of severe forms of psoriasis. The…

Therapeutic Strategies in Dermatology

Sweet’s Syndrome (Acute Febrile Neutrophil Dermatosis): Treatment

…ry. In severe or refractory disease cyclosporine A, 5-10 mg/kg per day may induce a response. It may be necessary to utilize cyclosporine (in addition to systemic steroids) with close monitoring for side effects. Response should be dramatic and will…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Treatment

…g ulcers. Subsequent steps If the response to systemic steroids is inadequate and the process is extremely rapid, treat with cyclosporine A at an initial dose of 5-10 mg/kg/day (in addition to systemic steroids) with close monitoring for side…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Treatment

…times be useful in refractory disease, especially if generalized. Their use has largely been replaced by the use of BTX and cyclosporine. Pitfalls The use of prophylactic systemic antibiotics should be avoided if possible, to minimize the emergence…

Therapeutic Strategies in Dermatology

Photosensitivity Dermatoses: Overview

…be required. Therapeutic options include the following: Azathioprine 50–200 mg daily. Mycophenolate mofetil 1 g twice daily Cyclosporine A 3–5mg/kg/day. Thalidomide 100–200 mg daily. An appropriate pregnancy prevention program must be used for…

Therapeutic Strategies in Dermatology

Hand Dermatitis: Treatment

…a thorough review of the patient’s exposures, including hobbies and occupational history. In severe refractory cases, cyclosporine A, mycophenolate mofetil, or alitretinoin may be necessary. Chronic hyperkeratotic hand dermatitis First steps…

Therapeutic Strategies in Dermatology

Epidermolysis Bullosa Acquisita: Overview

…en ineffective in EBA. Some patients with inflammatory lesions resembling bullous pemphigoid may respond to these therapies. Cyclosporine 5-9 mg/kg/day with or without prednisone may dramatically improve severe disease and induce a remission. Renal…

Therapeutic Strategies in Dermatology

Lichen Planus: Treatment

…ary. Use a medicated mouth rinse such as dexamethasone 5 mg/cc, (such as Decadron or Hexadrol – use 5 cc per rinse) or cyclosporine (100 mg/cc, 5 cc per rinse) that is gargled for 15-30 seconds and then spit out, 3 times daily. Apply topical…

Therapeutic Strategies in Dermatology

Lichen Sclerosus et Atrophicus: Overview

…s may be useful. Subsequent Therapy If topical treatment is ineffective, hydroxychloroquine 200 mg twice daily may be tried. Cyclosporine 3–4 mg/kg/day can be effective in refractory cases. Photodynamic therapy may be attempted in the most…

Therapeutic Strategies in Dermatology

Necrobiosis Lipoidica Diabeticorum: Overview

…n pain after several treatments. In severe refractory cases requiring systemic treatment, consider the following options: a. Cyclosporine 2.5-5 mg/kg per day for several months b. Mycophenolate mofetil 2-3 g/day c. Infliximab 5 mg/kg per treatment…