…eration T3 2.01-4.00 a: Without ulceration b: With ulceration T4 > 4.00 a: Without ulceration b: With ulceration N No. of Metastatic Nodes Nodal Metastatic Burden N0 0 NA N1 1 a: Micrometastasis* b: Macrometastasis† N2 2-3 a: Micrometastasis* b:…

…(signifying areas of regression) or more darkly pigmented raised areas (where the melanoma is arising). Malignant melanoma, metastatic Differential Diagnosis Melanocytic nevi Basal cell carcinoma, especially pigmented variants of basal cell…

…ng and dissection, which reveals 2 of 8 lymph nodes affected Brain, chest, abdominal, and pelvic CT scans reveal evidence of metastatic disease in the lung and liver. Blood work is normal Genetic testing is done, which reveals a BRAF V600E mutation….

…oma/HealthProfessional Robert C, Thomas L, Bondarenko I, et al. (2011). Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364 (26): 2517-26. Robert C, Ribas A, Wolchok JD, et al. (2014)….

References Gupta M, Huang V, Linette G, Cornelius L (2012). Unusual complication of vemurafenib treatment of metastatic melanoma: exacerbation of acantholytic dyskeratosis complicated by Kaposi varicelliform eruption, JAAD, 148:966-968. Norman R…

…d very closely for the evolution of NMSCs. UV (ultraviolet) light plays significant role in the pathogenesis of NMSC. Vismodegib is a new medical therapeutic option for the treatment of advanced local or metastatic basal cell carcinoma….

…couple control, as done for other cutaneous carcinomas, may be curative. When to refer to a dermatologist Clinical cases requiring Mohs micrographic surgery or photodynamic therapy. For management of patients with large, clinically-aggressive,…

…can and radiolabeled octreotide scan reveal a jejunoileal tumor highly suspicious for a midgut carcinoid tumor. There are no metastatic lesions noted on a subsequent MRI scan and cardiac studies are normal (no valvular lesions). She is referred for…