Search Results for: x-linked%20ichthyosis

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Therapeutic Strategies in Dermatology

Ichthyoses/Disorders of Cornification: Overview

…e. The hydroxy acids (i.e., lactic acid lotion, ammonium lactate gel, or glycolic acid lotion) are especially efficacious in X-linked ichthyosis, and may be the only specific therapy needed for this disease. Patients with acquired ichthyosis need to…

Therapeutic Strategies in Dermatology

Bullous Pemphigoid: Key Points

…with urticarial plaques with bullae, usually on the abdomen, and proximal thighs, and can involve the rest of the trunk or extend to the extremities as well. Oral involvement is uncommon, with 10-25% of patients having oral erosions due to BP….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…chthyosiform dermatoses. Arch Dermatol 1966;94:113–26. “There are four major types of ichthyosis: ichthyosis vulgaris, X-linked ichthyosis, ichthyosis congenita and epidermolytic hyperkeratosis (bullous ichthyosiform erythroderma). In…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blaschkitis?

…ko’s lines. Happle, in 1993, demonstrated that the lines of Blaschko become manifest in heterozygous states of various X-linked gene defects, such as incontinentia pigmenti, X-linked hypohidrotic ectodermal dysplasia, and focal dermal…

Differential Diagnosis in Dermatopathology

Discussions

…. As in all ichthyoses, the scales are thickest on the legs. Histopathologically, the scales of both ichthyosis vulgaris and X-linked ichthyosis consist entirely of cells orthokeratotic, none being parakeratotic. The turnover time of the epidermis…

Histologic Diagnosis of Inflammatory Skin Diseases

Non-bullous congenital ichthyosiform erythroderma

…onbullous congenital ichthyosiform erythroderma not related to any of the so-called ichthyoses, such as ichthyosis vulgaris, X-linked ichthyosis, and lamellar ichthyosis, but the exact nosologic status of it still is on debate. For sure it is an…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermis

…eratocytes one to another and hydrolysis of it to free cholesterol coincides with desquamation of corneocytes. Patients with X-linked ichthyosis lack steroid sulfatase, that absence preventing removal of cholesterol sulfate and, thereby, limiting…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ltrate of skin diseases in which mast cells have degranulated or in which antigen-antibody complexes have formed. In anaphylaxis, for example, a specific antigen binds antibodies that coat the surface of mast cells. Degranulation of mast cells…

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