Clinical Reference / Clinical Atlas / Allergic (Leukocytoclastic) Vasculitis

Allergic (Leukocytoclastic) Vasculitis


Definition

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations are urticarial papules, purpuric macules, papules, pustules, vesicles, and bullae, ulcers, and scars. The effects of the vasculitis on other organs are expressed variously, e.g., by gastrointestinal pain, hematuria, and arthritis.

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