Clinical Reference / Clinical Atlas / Erythema Nodosum

Erythema Nodosum

Definition

The most common form of eruptive inflammation in the subcutaneous fat, i.e., panniculitis, marked by tender, smooth and erythematous plaques, nodules, or tumors (or combinations thereof) that usually affect the anterior aspect of the legs and, less often, the arms or neck, of predominantly young women. The eruption may be induced by processes, in an organ other than the skin, as dissimilar as streptococcal pharyngitis, sarcoidosis, Crohn’s disease, and histoplasmosis.