The sequence chronologic of lesions of rosacea varies greatly because the lesions themselves vary so greatly. The mostly telangiectatic expression of rosacea simply worsens in time with more telangiectases appearing on the middle third of the face. Papules of rosacea may come and go for years or they may enlarge to become permanent nodules. The rhinophymatous manifestation of rosacea tends to worsen progressively and may be deforming.

In sum, only papular lesions of rosacea regress, and inconsistently; the telangiectatic and rhinophymatous expressions of rosacea tend to progress and worsen.