Search Results for: melanoma

Strategies for early recognition of cutaneous melanoma-present and future

Strategies for early recognition of cutaneous melanoma-present and future

…concise overview of general principles as well as current and future strategies for an improved early diagnosis of cutaneous melanoma Introduction Cutaneous melanoma is a highly aggressive malignant tumor of melanocytic origin with increasing…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidemic of Melanoma?

…moderate, or severe dysplasia.” By the 1980s, capable clinicians and competent histopathologists were able to diagnose melanoma when it was small and flat. Melanoma confined to epidermal and adnexal epithelium was then designated, by the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Precursor Lesions of Melanoma?

…f them are neoplasms composed of melanocytes, they have nothing in common! Lentigo maligna is a synonym for a flat lesion of melanoma (melanoma in situ) situated on skin that has been damaged badly by the effects of ultraviolet light. It cannot be a…

Nail matrix melanoma: consecutive cases in a general practice

Nail matrix melanoma: consecutive cases in a general practice

…76 by Reed [1]. Prior to that Clark had proposed three histologic sub-types: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma [2]. About half of all hand and foot melanomas are of the acral lentiginous subtype. A…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…h. Other terms applied to this stage of melanoma evolution include ‘precancerous melanosis,’ ‘plaque-stage melanoma’ and ‘nontumorigenic melanoma’.” Elder DE, Murphy GF. Malignant tumor (melanomas and…

Gajewski TF, Hodi FS. Targeted Therapeutics in Melanoma. New York: Springer, 2012

Gajewski TF, Hodi FS. Targeted Therapeutics in Melanoma. New York: Springer, 2012

melanomas; cells transform, but lesions do not. What is readily observable is that there are nevi, nevi in conjunction with melanomas, and melanomas. How a melanocyte eventually becomes a melanoma is as much an enigma today as it was when Clark et…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wide and Deep Excision for Melanoma?

…hould be to extract the melanoma completely, and to do nothing more. It makes no sense to perform wider excisions for deeper melanomas. If a melanoma, irrespective of size, has not metastasized by the time it is extirpated, complete excision with a…