Search Results for: basement%20membrane

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

…re as well as in other small blood vessels and may result in decreased cutaneous blood flow. Reduplication and thickening of basement membranes have been shown in diabetic skin. Veil cells are seen more frequently surrounding cutaneous vessels. It…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Paraneoplastic Pemphigus?

…erosions, and an array of histologic features, including (2) epidermal acantholysis and interface changes, (3) epidermal and basement membrane-zone deposition of IgG and complement as seen with direct immunofluorescence, (4) detection of serum…

Histologic Diagnosis of Inflammatory Skin Diseases

Linear IgA dermatosis

…e bullous pemphigoid. In contrast to the situation in linear IgA dermatosis in which IgA is deposited in linear array at the basement membrane zone, in dermatitis herpetiformis, IgA is distributed as granules at the basement zone and dermal…

Differential Diagnosis in Dermatopathology

Lichen planus vs. Lichenoid discoid lupus erythematosus

An inflammatory disease of the second and third trimesters of pregnancy characterized by widespread urticarial papules and plaques accompanied by vesicles and bullae. Individual lesions are indistinguishable from those of bullous pemphigoid,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus Versus Systemic Lupus Erythematosus?* I

…icial and deep perivascular infiltrates of lymphocytes, plentiful mucin in the reticular dermis, and, sometimes, a thickened basement membrane beneath a thinned epidermis. The tumid expression of lupus erythematosus shows all the attributes…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…ualized through an electron microscope, consists of a lamina lucida and a lamina densa, and contains molecules common to all basement membranes. At about 12 weeks, the dermoepidermal interface is punctuated at intervals nearly equidistant from one…

Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Intraepithelial Fluorescence

…tered concurrently. Likewise, in some instances of pemphigus erythematosus, granular deposits of some immunoglobulins at the basement membrane zone are met with, those being evidence additionally in favor of that diagnosis. In IgA pemphigus…

Differential Diagnosis in Dermatopathology

Atrophic lichen planus vs. Atrophic discoid lupus erythematosus

An inflammatory disease of the second and third trimesters of pregnancy characterized by widespread urticarial papules and plaques accompanied by vesicles and bullae. Individual lesions are indistinguishable from those of bullous pemphigoid,…