Search Results for: basement%20membrane

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Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…d lesions demonstrates granular deposits of one or more immunoglobulins (two concurrently being virtually diagnostic) at the basement membrane zone (in patients with widespread disease, findings identical can be seen in clinically normal skin [a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Inverted Follicular Keratosis, Tricholemmoma, and Desmoplastic Tricholemmoma?

…ut follicular infundibula, basaloid palisading at the periphery of tumor lobules, and development of a thickened, hyalinized basement membrane.” Murphy G. Adnexal tumors. In: Dermatopathology: A Practical Guide to Common Disorders….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

…re as well as in other small blood vessels and may result in decreased cutaneous blood flow. Reduplication and thickening of basement membranes have been shown in diabetic skin. Veil cells are seen more frequently surrounding cutaneous vessels. It…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Paraneoplastic Pemphigus?

…erosions, and an array of histologic features, including (2) epidermal acantholysis and interface changes, (3) epidermal and basement membrane-zone deposition of IgG and complement as seen with direct immunofluorescence, (4) detection of serum…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Subacute Cutaneous Lupus Erythematosus?

…mination between SCLE and DLE was accomplished in 82%. The specimens from DLE lesions had substantially more hyperkeratosis, basement membrane thickening, follicular plugging, and superficial and deep inflammatory cell infiltrate, while SCLE had…

Histologic Diagnosis of Inflammatory Skin Diseases

Linear IgA dermatosis

…e bullous pemphigoid. In contrast to the situation in linear IgA dermatosis in which IgA is deposited in linear array at the basement membrane zone, in dermatitis herpetiformis, IgA is distributed as granules at the basement zone and dermal…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus Versus Systemic Lupus Erythematosus?* I

…icial and deep perivascular infiltrates of lymphocytes, plentiful mucin in the reticular dermis, and, sometimes, a thickened basement membrane beneath a thinned epidermis. The tumid expression of lupus erythematosus shows all the attributes…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…ualized through an electron microscope, consists of a lamina lucida and a lamina densa, and contains molecules common to all basement membranes. At about 12 weeks, the dermoepidermal interface is punctuated at intervals nearly equidistant from one…

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