Search Results for: ballooning

Differential Diagnosis in Dermatopathology

Allergic contact dermatitis vs. Irritant contact dermatitis

First alluded to by Feldaker in 1955, livedoid vasculopathy is a rare small vessel coagulopathy limited to the skin that occurs especially in the vicinity of the ankle (malleolus). Lesional morphology is characterized at first by purpuric macules…

An itchy rash in a young Caucasian woman

An itchy rash in a young Caucasian woman

…e changes, a skin biopsy taken from a fully developed inframammary lesion displayed dramatic epidermal changes consisting of ballooning of keratinocytes, necrosis en masse of keratinocytes with intraepidermal vesiculation and exocytosis of…

Histologic Diagnosis of Inflammatory Skin Diseases

Drug eruptions

…erivascular dermatitis, to wit, perivascular only; perivascular and interstitial; interface, vacuolar, interface, lichenoid; ballooning; spongiotic, and psoriasiform. Of these, interface dermatitis is the most common, and psoriasiform dermatitis is…

Differential Diagnosis in Dermatopathology

Pityriasis lichenoides acuta vs. Pityriasis lichenoides chronica

First alluded to by Feldaker in 1955, livedoid vasculopathy is a rare small vessel coagulopathy limited to the skin that occurs especially in the vicinity of the ankle (malleolus). Lesional morphology is characterized at first by purpuric macules…

Histologic Diagnosis of Inflammatory Skin Diseases

Erysipelas

…cytes around venules Marked edema of the papillary dermis, sometimes eventuating in subepidermal vesiculation Spongiosis and ballooning may be so extensive that an intraepidermal blister forms Numerous erythrocytes extravasated in the upper part of…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…s disposed as solitary units positioned in the lower portion of the epidermis mostly and often in infundibula Spongiosis and ballooning of variable extent; intraepidermal vesiculation uncommon, but blisters may rupture and become subepidermal…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ly ballooned keratocytes in company with neutrophils in the upper half of the epidermis = Irritant contact dermatitis Severe ballooning of keratocytes confined to the upper half of the epidermis indicates that the lesion was induced by injury…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

…some instances Necrosis of the epidermis often follows on reticular alteration that comes into being secondary to pronounced ballooning Neutrophils in the necrotic epidermis Late All the findings in lesions developed fully plus: Erosions and/or…

Differential Diagnosis in Dermatopathology

Erythema multiforme vs. Graft-versus-host disease, acute phase

First alluded to by Feldaker in 1955, livedoid vasculopathy is a rare small vessel coagulopathy limited to the skin that occurs especially in the vicinity of the ankle (malleolus). Lesional morphology is characterized at first by purpuric macules…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…t infiltrate of neutrophils mostly + 10.11.4C + 10.11.4D = Burn The blister shown began in the epidermis as a consequence of ballooning that led to epidermal necrosis; on rupture, the intraepidermal blister became subepidermal, too. Neutrophils are…