Search Results for: vesicle

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Method for Surgery

…thologist with sections from which an element critical for diagnosis, i.e., the epidermis, is missing (Fig. 4.1). Tiny tense vesicles, such as those of miliaria crystallina, dyshidrotic dermatitis, and infection by herpesvirus, are an exception to…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria

…ate of lymphocytes and eosinophils in conjunction with edema of the papillary dermis and spongiosis (sometimes, a spongiotic vesicle) in the epidermis at the site of the “bite.” Laboratory confirmation None exists. Cause and mechanism…

Histologic Diagnosis of Inflammatory Skin Diseases

Suction blister

Suction blister Presentation stereotypical Individual lesions Vesicles and bullae Findings histopathologic Fully developed Subepidermal blister beneath which dermal papillae are preserved No infiltrate of inflammatory cells Correlation…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…ils; BC, basal cell; D, dermis; HD, hemidesmosome; LD, lamina densa; LL, lamina lucida; PM, plasma membrane; PV, pinocytotic vesicle. (x67,500) (Courtesy of Stephen Katz, M.D.) The plasma membrane of basal keratocytes forms the roof of the…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…but one of many expressions of leukocytoclastic vasculitis clinical (others being purpuric macules, purpuric and nonpurpuric vesicles, and ulcers), and, moreover, diseases unrelated to leukocytoclastic vasculitis (lichenoid purpura of Gougerot and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ls in the dermis and in vesicles in the epidermis = Bullous pemphigoid, vesicular Both authentic intraepidermal (spongiotic) vesicles and subepidermal vesicles are present. In addition, some intraepidermal vesicles have ruptured to become…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…rilesional” zone should be noneroded, noncrusted, and nonvesicular. With rare exceptions, a biopsy specimen of a frank vesicle is useless for interpretation by direct immunofluorescence. In contrast, a biopsy performed for direct…