Search Results for: vesicle

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…rilesional” zone should be noneroded, noncrusted, and nonvesicular. With rare exceptions, a biopsy specimen of a frank vesicle is useless for interpretation by direct immunofluorescence. In contrast, a biopsy performed for direct…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…but one of many expressions of leukocytoclastic vasculitis clinical (others being purpuric macules, purpuric and nonpurpuric vesicles, and ulcers), and, moreover, diseases unrelated to leukocytoclastic vasculitis (lichenoid purpura of Gougerot and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ls in the dermis and in vesicles in the epidermis = Bullous pemphigoid, vesicular Both authentic intraepidermal (spongiotic) vesicles and subepidermal vesicles are present. In addition, some intraepidermal vesicles have ruptured to become…

Histologic Diagnosis of Inflammatory Skin Diseases

Suction blister

Suction blister Presentation stereotypical Individual lesions Vesicles and bullae Findings histopathologic Fully developed Subepidermal blister beneath which dermal papillae are preserved No infiltrate of inflammatory cells Correlation…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s, intraepidermal, spongiotic + 10.88.6B: Collections of neutrophils beneath the cornified layer at the side of a spongiotic vesicle. + 10.88.6C + 10.88.6D: = Prurigo pigmentosa Vesicles in prurigo pigmentosa may come into being by virtue of…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…pesvirus infection, fully developed If this lesion had not been interrupted by biopsy, the tension within the intraepidermal vesicle would have caused it to burst and to become subepidermal, too; only a single layer of basal keratocytes remains at…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…necrosis of the epidermis follows on severe ballooning and reticular alteration that are accompaniments of an intraepidermal vesicle. 10.99.3A: Vasculitis, small vessel, neutrophilic + 10.99.3B: Perivascular and interstitial mixed-cell infiltrate…