Search Results for: xanthogranuloma

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…c cells; they are inflammatory cells. What just has been said for some examples of dermatofibroma applies equally to some of xanthogranuloma, that inflammatory process sometimes exhibiting “monster cells.” Another pitfall for general…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…with scattered lymphocytes and plasma cells, the infiltrate forming nodules, are requisite for the diagnosis. This is not a xanthogranuloma because the cytoplasm of histiocytes is not foamy and because Touton giant cells are not present….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.24.1A: Nodular dermatosis + 11.24.1B: Foamy histiocytes in a papule = Xanthoma A xanthoma differs from a xanthogranuloma by being made up of a nearly pure population of foamy histiocytes, practically none of which are multinucleate, and…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

…at its surface by continuity with infundibular epidermis. These are not the changes of granuloma annulare or of necrobiotic xanthogranuloma. Because we are unable to come to a diagnosis with assurance, the diagnosis issued in a report must be…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

…ere is no evidence of emperipolesis. Indeterminate cell histiocytosis lacks emperipolesis. Reticulohistiocytoma is a type of xanthogranuloma in which cytoplasm of histiocytes is abundant and amphophilic. Xanthogranuloma exhibits neither large…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…it is degenerated collagen along with deposits of lipid in conjunction with cholesterol clefts, the diagnosis is necrobiotic xanthogranuloma. How the changes in the locus in the center of the palisade of histiocytes come to occur is not known, but…

Differential Diagnosis in Dermatopathology

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Xanthogranuloma Necrobiotic xanthogranuloma

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudomalignancies?

…Pseudomalignancies usually are benign neoplasms, but, rarely, they may be inflammatory diseases, such as dermatofibromas and xanthogranulomas with “monster cells.” Irrespective of the essential nature of the process pathologic, the term…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hages, some of them of Touton type + 10.20.24C + 10.20.24D = Dermatofibroma Touton giant cells are not specific for juvenile xanthogranuloma, but may be encountered in other conditions, including dermatofibroma, as shown here. 10.20.25A: Fibrosing…