Search Results for: melanocytes

Regression of nevi in a melanoma patient treated with interferon

Regression of nevi in a melanoma patient treated with interferon

…lanoma-associated leukoderma. These phenomena result from an immune reaction against shared antigens on benign and malignant melanocytes [5,6]. Hu and colleagues described primary melanomas presenting as inflamed pigmented lesions during adjuvant…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

…eratocytes by a space, a finding that for more than a century caused them to be interpreted incorrectly as “high-level melanocytes.” In fact, the space that surrounds Langerhans” cells is an artifact caused by shrinkage during…

In vivo intraoral reflectance confocal microscopy of an amalgam tattoo

In vivo intraoral reflectance confocal microscopy of an amalgam tattoo

…ls suggesting a reactive lymphohistiocytic infiltrate. To better characterize these findings, immunohistochemical stains for melanocytes and Langerhans cells were performed. These showed normal numbers of melanocytes within the basal and…

An irregular pigmented lesion on the back

An irregular pigmented lesion on the back

…ust a coincidental collision between tumors [2]. These mutations may result in an altered cell-to-cell communication between melanocytes and keratinocytes that would lead to an abnormal proliferation of melanocytes and/or keratinocytes [2]. Taking…

Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update

Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update

…howed a widespread derma atrophy (B) with large sheets of epithelioid cells at the junction (C); cytomorphologically, dermal melanocytes were epithelioid but devoid of true ‘Spitzoid’ features (D). The excision specimen showed a bland junctional…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Changing Mole?

…nge independently should be cause for alarm.” Rhodes AR. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al., eds., Dermatology in general medicine. 4th ed. New York:…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Borderline, Minimal Deviation, and Nevoid Melanomas?

…potential for metastasis.” “Six forms of minimal deviation melanoma have been described . . . A small nodule of melanocytes that show moderate to moderately severe atypism and impinge on the reticular dermis . . . Minimal deviation…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophie Blanche?

…f months, as a result of sclerosis, loss of melanin from epidermal keratocytes into dermal melanophages and impotence of the melanocytes remaining at those sites, lesions become white macules and atrophic patches. The term atrophie blanche…

Histologic Diagnosis of Inflammatory Skin Diseases

Tinea nigra

…olor. Potassium hydroxide preparation is negative for fungi in the cornified layer of benign and malignant proliferations of melanocytes. Stain of skin by silver nitrate has an unnatural appearance because it is caused artifactually. It can be…