Search Results for: melanocytes

Regression of nevi in a melanoma patient treated with interferon

Regression of nevi in a melanoma patient treated with interferon

…lanoma-associated leukoderma. These phenomena result from an immune reaction against shared antigens on benign and malignant melanocytes [5,6]. Hu and colleagues described primary melanomas presenting as inflamed pigmented lesions during adjuvant…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…nevus is one of many synonyms for Spitz nevus. To date, there has yet to be a comprehensible description of the epithelioid melanocytes said to constitute that distinctive nevus. Because, in times past, the phrase “spindle and/or epithelioid…

Non-choroidal yellow melanoma showing positive staining with Sudan Black consistent with the presence of lipofuscin: a case report

Non-choroidal yellow melanoma showing positive staining with Sudan Black consistent with the presence of lipofuscin: a case report

…s a nodular, well circumscribed proliferation of melanocytes (Figure 3). There was a proliferation of cytologically abnormal melanocytes and some confluent nests of melanocytes at the dermoepidermal junction (Figure 5), and the junctional…

An irregular pigmented lesion on the back

An irregular pigmented lesion on the back

…ust a coincidental collision between tumors [2]. These mutations may result in an altered cell-to-cell communication between melanocytes and keratinocytes that would lead to an abnormal proliferation of melanocytes and/or keratinocytes [2]. Taking…

Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update

Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update

…howed a widespread derma atrophy (B) with large sheets of epithelioid cells at the junction (C); cytomorphologically, dermal melanocytes were epithelioid but devoid of true ‘Spitzoid’ features (D). The excision specimen showed a bland junctional…

Histologic Diagnosis of Inflammatory Skin Diseases

Merkel Cells

…f any seeming association with neural elements. Merkel cells appear in fetal skin by the 16th week of gestation, and, unlike melanocytes, they do not come from the neural crest, and, unlike Langerhans” cells, they do not come from the bone…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Borderline, Minimal Deviation, and Nevoid Melanomas?

…potential for metastasis.” “Six forms of minimal deviation melanoma have been described . . . A small nodule of melanocytes that show moderate to moderately severe atypism and impinge on the reticular dermis . . . Minimal deviation…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophie Blanche?

…f months, as a result of sclerosis, loss of melanin from epidermal keratocytes into dermal melanophages and impotence of the melanocytes remaining at those sites, lesions become white macules and atrophic patches. The term atrophie blanche…

Histologic Diagnosis of Inflammatory Skin Diseases

Tinea nigra

…olor. Potassium hydroxide preparation is negative for fungi in the cornified layer of benign and malignant proliferations of melanocytes. Stain of skin by silver nitrate has an unnatural appearance because it is caused artifactually. It can be…

Complete regression of a melanocytic nevus after epilation with diode laser therapy

Complete regression of a melanocytic nevus after epilation with diode laser therapy

…he preferential targeting of melanin in the hair follicle over melanin in the epidermis. In a nevus, the increased number of melanocytes and melanin suggests that the photons of the laser for hair removal might be absorbed by the neoplastic…