The distinction histopahologically between Spitz’s nevus and primary cutaneous melanoma is one of the most vexing in all of pathology, and it has been so since 1910 when Darier and Civatte first struggled with the matter of the precise nature of the melanocytic neoplasm known universally to be benign. The conundrum for those two French dermatologists/dermatopathologists was expressed directly in the title of their article, to wit, “Is it nevus or nevo-carcinoma?” That the same quandary continues to dog histopathologists to this day is apparent from the popularity of terms such as atypical Spitz’s nevus, malignant Spitz’s nevus, and metastasizing Spitz’s nevus, all three of which are the subject of this essay.
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Published Year: 2004
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