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Therapeutic Strategies in Dermatology

Melanoma: Treatment

…nded. Patients with higher risk lesions (over 1 mm thick or < 1 mm with aggressive features such as ulceration or mitotic index >1 per mm2) should be considered for more extensive baseline evaluation such as sentinel lymph node biopsy and/or…

Therapeutic Strategies in Dermatology

Erythema Annulare Centrifugum: Overview

…eumatic fever; and necrolytic migratory erythema, which is associated with a glucagon-secreting tumor. Treatment First Steps Search for an underlying cause, specifically tinea pedis or cruris. A complete physical examination is required, especially…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

…gnant melanoma is determined by the histopathologic features (primarily tumor thickness, ulceration, regression, and mitotic index), by the location of the tumor, by the presence of regional or distant metastases and by the patient characteristics…

Therapeutic Strategies in Dermatology

Melanoma: Clinical Cases

…entify any other suspicious lesions Biopsy: melanoma, 0.7 mm thickness, Clark’s level II. No ulceration present, and mitotic index <1 per mm2 She is diagnosed with Stage 1a melanoma Follow-up The patient goes for wide local excision with 1 cm...

Therapeutic Strategies in Dermatology

Erythema Multiforme: Treatment

…First-line treatment is supportive care. Diagnostic management should entail consideration of a skin biopsy and a reasonable search for potential triggers that can be eliminated or treated. Diagnostic considerations include: viral direct…

Therapeutic Strategies in Dermatology

Facial Melanosis, Melasma: References

…atic Reviews, 7: ArtCD003583. Pandya AG et al (2011). Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method, JAAD, 64: 78-83. Ortonne JP (2006). Retinoid therapy of pigmentary…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…alysis of six clinical trials involving 4,118 patients demonstrated increased rates of achieving Psoriasis Area and Severity Index (PASI) scores of 75, 90, and 100% over placebo (risk ratios 12.61, 28.72, and 61.23, respectively). Therapy of plaque…

Therapeutic Strategies in Dermatology

Venous Stasis: Treatment

…insufficiency may coexist. Determining the ratio of the diastolic blood pressure in the leg versus. the arm (ankle-brachial index, or ABI) is recommended in all patients, as standard methods for healing venous ulcerations may be ineffective in the…

Therapeutic Strategies in Dermatology

Allergic Contact Dermatitis: Treatment

…bleach baths (1/4 cup of bleach in a full tub of lukewarm water, soaking 10-15 minutes) every other day. Subsequent therapy Search for the suspected irritant/allergen: In many cases of contact dermatitis, the cause is apparent, but some cases may…

Therapeutic Strategies in Dermatology

Cheilitis Granulomatosa: Overview

…native Steps Prescribe oral prednisone 40-60 mg/day (0.5-1.0 mg/kg/day) for 2-3 weeks, then taper the dose. Subsequent Steps Search for underlying dental or sinus inflammation. The treatment of these hidden foci of infection may lead to improvement…

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